Intracortical inhibition abnormality during the remission phase of multiple sclerosis is related to upper limb dexterity and lesions
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- 作者：Julia C. Nantesa ; b ; julia.nantes@mail.mcgill.ca" class="auth_mail" title="E-mail the corresponding author ; Jidan Zhongb ; c ; jidan.zhong@mail.mcgill.ca" class="auth_mail" title="E-mail the corresponding author ; Scott A. Holmesa ; b ; scott.holmes@mail.mcgill.ca" class="auth_mail" title="E-mail the corresponding author ; Benjamin Whatleya ; b ; bwhatley@dal.ca" class="auth_mail" title="E-mail the corresponding author ; Sridar Narayananc ; d ; sridar.narayanan@mcgill.ca" class="auth_mail" title="E-mail the corresponding author ; Yves Lapierred ; yves.lapierre@mcgill.ca" class="auth_mail" title="E-mail the corresponding author ; Douglas L. Arnoldd ; douglas.arnold@mcgill.ca" class="auth_mail" title="E-mail the corresponding author ; Lisa Koskib ; c ; lisa.koski@mcgill.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：RRMS ; relapsing-remitting multiple sclerosis ; RRMS-P ; RRMS participant with preserved motor function ; RRMS-I ; RRMS participant with impaired motor function ; HC ; healthy control ; GABA ; γ-aminobutyric acid ; TMS ; transcranial magnetic stimulation ; M1 ; primary motor cortex ; SICI ; short-interval intracortical inhibition ; CSP ; cortical silent period ; EDSS ; Expanded Disability Status Scale ; CSTi ; intracortical cortico-spinal tract ; MSFC ; Multiple Sclerosis Functional Composite ; T25FW ; Timed 25-foot wal
- 刊名：Clinical Neurophysiology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：127
- 期：2
- 页码：1503-1511
- 全文大小：798 K
文摘
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Cortical silent period (CSP) prolongation is related to upper extremity impairment of people with relapsing-remitting multiple sclerosis (RRMS) in remission.
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Normalized lesion volume is correlated with longer CSP duration, while cortical thickness is not.
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CSP duration predicts motor impairment independently of lesion volume.