Adolescents with Classical Polycystic Ovary Syndrome Have Alterations in the Surrogate Markers of Cardiovascular Disease but Not in the Endothelial Function. The Possible Benefits of Metformin

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• 作者：Franca Fruzzetti ; MD¹ ; ^{ffruzzi@tin.it" class="auth_mail" title="E-mail the corresponding author} ; Lorenzo Ghiadoni ; MD² ; Agostino Virdis ; MD² ; Ferdinando De Negri ; MD² ; Daria Perini ; MD¹ ; Fiorella Bucci ; MD¹ ; Chiara Giannarelli ; MD² ; Angiolo Gadducci ; MD¹ ; Stefano Taddei ; MD²
• 关键词：Endothelium ; Arterial stiffness ; Fibrinolysis ; Metformin ; PCOS
• 刊名：Journal of Pediatric and Adolescent Gynecology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：29
• 期：5
• 页码：489-495
• 全文大小：370 K

文摘

To study whether adolescents with the classical form of polycystic ovary syndrome (PCOS) have alterations in metabolic and vascular structure and function. The effect of metformin was evaluated.

Design

Controlled study.

Setting

University outpatient clinic.

Participants

Eighteen nonobese adolescents with PCOS were enrolled. Seventeen healthy age-matched adolescents were recruited as control subjects.

Interventions

The metabolic profile and the endothelial structure and function were evaluated.

Main Outcome Measures

Hormonal and lipid profile, blood pressure (BP) measurement, fasting glucose and insulin levels, C-reactive protein (CRP), homocysteine, tissue-type plasminogen activator, plasminogen activator inhibitor-1 (PAI-1), and plasmin-antiplasmin complexes (PAP) were measured. Flow mediated dilation (FMD), central pulse wave velocity (PWV), radial artery pulse wave, and common carotid intima-media thickness (IMT) were also assessed. Girls with PCOS were also studied 6 months after treatment with metformin (850 mg twice per day).

Results

Adolescents with PCOS were insulin resistant and/or hyperinsulinemic and they had higher BP values and levels of CRP and PAI-1 than the control subjects. The levels of tissue-type plasminogen activator and PAP were similar in both groups. FMD, PWV, and IMT were also similar. Metformin significantly (P < .05) reduced insulin, BP, CRP, and PAI-1 levels. The PAP levels significantly (P < .05) increased. Radial artery pulse wave was significantly reduced after metformin treatment. No modifications in FMD, PWV, and IMT were observed.

Conclusion

Adolescents with classical PCOS have alterations in some surrogate markers of cardiovascular risk and they are ameliorated by metformin. No deterioration of vascular structure and function has been detected, probably because of the short duration of exposure to the disease.