A Detailed Analysis of the Association Between Postoperative Phosphodiesterase Type 5 Inhibitor Use and the Risk of Biochemical Recurrence After Radical Prostatectomy

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• 作者：Andrea Gallina ; Marco Bianchi ; Giorgio Gandaglia ; Vito Cucchiara ; Nazareno Suardi ; Francesco Montorsi ; Alberto Briganti ; ^{briganti.alberto@hsr.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Prostate cancer ; Radical prostatectomy ; Phosphodiesterase type 5 inhibitors ; Biochemical recurrence
• 刊名：European Urology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：68
• 期：5
• 页码：750-753
• 全文大小：192 K

文摘

A recent study reported a detrimental effect of phosphodiesterase type 5 inhibitors (PDE5-Is) on biochemical recurrence (BCR) after radical prostatectomy (RP) for prostate cancer (PCa). We tested the association between PDE5-I use, PDE5-I therapy scheme, number of PDE5-I pills taken, and BCR in 2579 patients treated with bilateral nerve-sparing RP for PCa between 2004 and 2013 at a single center. Patients were categorized according to PDE5-I use within 2 yr after surgery as on demand, rehabilitation schedule (daily PDE5-I use for at least 3 mo), and no PDE5-I use. Multivariable (MVA) Cox regression models tested the association between PDE5-I and BCR. The same analyses were repeated using the number of PDE5-I pills taken by each patient. Overall, 674 patients (26.1%) received PDE5-Is. At MVA analysis, PDE5-I use, type of administration schedule, and number of PDE5-I pills were not significantly associated with higher risk of BCR (all p ≥ 0.2) after accounting for multiple confounders including time from RP to PDE5-I use. While awaiting further studies, patients should not be denied PDE5-I treatment after RP.

Patient summary

Among patients treated with radical prostatectomy, phosphodiesterase type 5 inhibitor use was not associated with an increased risk of biochemical recurrence, regardless of the therapeutic regimen used.