Blunted inflammatory and mucosal IgA responses to pneumonia virus of mice in C57BL/6 neonates are correlated to reduced protective immunity upon re-infection as elderly mice
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- 作者：Pratima Shrivastavaa ; Ethel Atanleya ; b ; Indranil Sarkara ; b ; Ellen Watkissa ; c ; Susantha Gomisd ; Sylvia van Drunen Littel-van den Hurka ; b ; 1 ; sylvia.vandenhurk@usask.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：BALB/c ; C57BL/6 ; Neonates ; Primary infection ; Elderly mice ; Re-infection ; PVM ; IgG ; IgA ; pDCs ; IFN
- 刊名：Virology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：485
- 期：Complete
- 页码：233-243
- 全文大小：3735 K
文摘
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PVM causes more severe disease in BALB/c than in C57BL/6 neonates.
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BALB/c neonates develop a stronger inflammatory response to PVM than C57Bl/6 neonates.
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BALB/c neonates have more IgA in the lungs than C57BL/6 neonates after PVM infection.
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After re-infection as elderly, BALB/c but not C57Bl/6 mice are protected from PVM.
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Re-infected elderly BALB/c mice develop high neutralizing antibodies.