IL-12p40 gene-deficient BALB/c mice exhibit lower weight loss, reduced lung pathology and decreased sensitization to allergen in response to infection with pneumonia virus of mice
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- 作者：Pratima Shrivastavaa ; Indranil Sarkara ; b ; Ethel Atanleya ; b ; Susantha Gomisc ; Sylvia van Drunen Littel-van den Hurka ; b ; sylvia.vandenhurk@usask.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：BALB/c ; IL-12p40-/- ; Regulatory T cells ; Pneumonia virus of mice ; Allergen
- 刊名：Virology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：497
- 期：Complete
- 页码：1-10
- 全文大小：1577 K
文摘
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IL-12 was more up-regulated in response to PVM in BALB/c than in C57BL/6 mice.
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IL-12p40-/- and wild-type neonatal and adult BALB/c mice were challenged with PVM.
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IL-12p40-/- mice showed less weight loss than wild-type mice after PVM challenge.
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The percentage of regulatory T cells was higher in the lungs of IL-12p40-/- mice.
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IL-12p40-/- mice showed greatly decreased allergic sensitization after PVM infection.