Induction of long term mucosal immunological memory in humans by an oral inactivated multivalent enterotoxigenic Escherichia coli vaccine
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- 作者：Anna Lundgren ; anna.lundgren@microbio.gu.se" class="auth_mail" title="E-mail the corresponding author ; Marianne Jertborn marianne.jertborn@microbio.gu.se" class="auth_mail" title="E-mail the corresponding author ; Ann-Mari Svennerholm ann-mari.svennerholm@microbio.gu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：AE ; adverse event ; ALS ; antibodies in lymphocyte supernatants/secretions ; ASC ; antibody-secreting cell ; BAFF ; B cell activating factor ; CF ; colonization factor ; CT ; cholera toxin ; CTB ; cholera toxin binding subunit ; dmLT ; double mutant LT ; ETEC ; enterotoxigenic Escherichia coli ; GM ; geometric mean ; LT ; heat labile toxin ; LTB ; heat labile toxin binding subunit ; LCTBA ; CTB/LTB hybrid protein ; LPS ; lipopolysaccharide ; MEV ; multivalent ETEC vaccine ; PBMCs ; peripheral blood mononuclear cells ; PPS ; pe
- 刊名：Vaccine
- 出版年：2016
- 出版时间：8 June 2016
- 年：2016
- 卷：34
- 期：27
- 页码：3132-3140
- 全文大小：1142 K
文摘
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The capacity of an oral killed ETEC vaccine to induce mucosal IgA memory was tested.
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The vaccine consisted of a toxoid and E. coli over-expressing colonization factors.
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The vaccine induced mucosal IgA memory to all major vaccine antigens.
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The mucosal immunological memory remained ≥1–2 years after priming vaccination.
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Kinetics of antibody-secreting cell responses can be used to assess immune memory.