A critical role of interleukin-1 in preterm labor
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- 作者：Mathieu Nadeau-Vallé ; ea ; bAuthor Vitae ; Dima ObaribAuthor Vitae ; Christiane QuiniouaAuthor Vitae ; William D. LubellcAuthor Vitae ; David M. OlsondAuthor Vitae ; Sylvie Girarde ; sylvie.girard@recherche-ste-justine.qc.ca" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Sylvain Chemtoba ; sylvain.chemtob@umontreal.ca" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：AF ; amniotic fluids ; AP-1 ; activator protein-1 ; CSAIDs ; cytokine suppressive anti-inflammatory drugs ; DAMPs ; damage-associated molecular patterns ; ECM ; extracellular matrix ; fFN ; fetal fibronectin ; HPA ; hypothalamic-pituitary-adrenal ; IKK ; IκB kinase ; IL ; interleukin ; IL-1R ; interleukin-1 receptor ; IL-1Ra ; interleukin-1 receptor antagonist ; IL-1RAcP ; interleukin-1 receptor accessory protein ; IRAK ; interleukin-1 receptor-activated protein kinase ; LMA ; leukocyte migration assay ; LPS ; lipopolysacch
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：28
- 期：Complete
- 页码：37-51
- 全文大小：2554 K
文摘
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This work highlights the importance of interleukin-1 in human preterm labor, as well as efforts to identify safe and potent IL-1-targeting agents and diagnostics with high negative and positive predictive value to respectively treat and identify women at risk of preterm deliveries.
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Tandem use of new diagnostics and therapies will incentivise development of effective clinical modalities to tackle this unmet medical need.