Palladium nanoparticles enzyme aggregate (PANEA) as efficient catalyst for Suzuki-Miyaura reaction in aqueous media

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• 作者：Teresa Cuenca ; Marco Filice ; ^{marco.filice1@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Jose M. Palomo ; ^{josempalomo@icp.csic.es" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Suzuki&ndash ; Miyaura ; Palladium ; Artificial enzyme ; Nanocatalysis ; Heterogeneous catalysis ; Aqueous media
• 刊名：Enzyme and Microbial Technology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：95
• 期：Complete
• 页码：242-247
• 全文大小：1238 K

文摘

Palladium nanoparticles enzyme aggregate (PANEA) were prepared from Candida antarctica B lipase and palladium salt by precipitation and subsequent in situ Pd nanoparticle formation. This heterogeneous catalyst was successfully used for the Suzuki–Miyaura cross-coupling reaction between bromobenzene with different phenylboronic acid derivatives under mild reaction conditions and using low Pd amount. The nanocatalyst exhibited the highest catalytic activity in a mixture of methanol/water (1:1), obtaining good to excellent product yields from the cross-coupling reaction. A variety of functional groups were accepted and the catalyst was recycled 4 times without activity loss.