NT-3 protein levels are enhanced in the hippocampus of PRG1-deficient mice but remain unchanged in PRG1/LPA2 double mutants
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- 作者：Sandra Petzolda ; Babette Sommera ; Andrea Krö ; bera ; Robert Nitschb ; Herbert Schweglera ; Johannes Vogtb ; 1 ; Thomas Roskodena ; 1 ; thomas.roskoden@med.ovgu.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Plasticity-related gene 1 (PRG1) ; Lysophosphatidic acid 2 receptor (LPA2R) ; Neurotrophic factors ; Hippocampus ; Mouse
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：26 January 2016
- 年：2016
- 卷：612
- 期：Complete
- 页码：145-148
- 全文大小：563 K
文摘
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In PRG1 ko mice protein level of NT-3 is increased against WT, NGF and BDNF not.
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In LPA2R knockout mice no neurotrophin (NGF, BDNF, NT-3) is changed compared to WT.
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In PRG1LPA2R double Ko mice no changes were observed in NGF, BDNF and NT-3 protein.