• 作者：Sebastian Dietmar Barth^a ; ^{s.barth@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Rudolf Kaaks^a ; ^{r.kaaks@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Theron Johnson^a ; ^{t.johnson@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Verena Katzke^a ; ^{v.katzke@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Katharina Gellhaus^b ; ^{katharina.gellhaus@epiontis.com" class="auth_mail" title="E-mail the corresponding author} ; Janika Josephin Schulze^b ; ^{janika.schulze@epiontis.com" class="auth_mail" title="E-mail the corresponding author} ; Sven Olek^b ; ^{sven.olek@epiontis.com" class="auth_mail" title="E-mail the corresponding author} ; Tilman Kü ; hn^a ; ^{t.kuehn@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Foxp3  ; + regulatory T cells (Tregs) ; Cell-type-specific epigenetic qPCR-assays ; Immune tolerance ; Prospective study ; Cardiovascular disease risk
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：11
• 期：Complete
• 页码：151-156
• 全文大小：283 K

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We studied if peripheral immune tolerance, as reflected by regulatory (FOXP3+) to total (CD3+) T cells, relates to CVD risk.

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Epigenetic-based, qPCR assisted cell counting was used to quantify T cell subsets in long-term stored buffy coat samples.

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Lower Treg-mediated immune tolerance does not confer an increased risk of major CVD events.

Inflammation in the arterial intima plays a central role in atherosclerotic cardiovascular disease and may develop owing to autoimmune-like responses targeted against plaque antigens. While the ratio between regulatory T cells (Tregs) and effector T cells is thought to control such immune response outcomes and tolerance within the T cell compartment, we found no association with incidence of major CVD events. These findings imply that reduced systemic Treg frequencies observed in CVD patients follow rather than precede disease manifestation and that Treg variation within a physiological range may not – as previously reported - constitute a pre-disposing risk factor for CVD.