Development and validation of a dissolution test for lutein tablets and evaluation of intestinal permeability
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- 作者：Carina de Souza Anselmo ; Thamara de Carvalho Mendes ; Thiago da Silva Honorio ; Flá ; via Almada do Carmo ; Lucio Mendes Cabral ; Valeria Pereira de Sousa ; valeria@pharma.ufrj.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dissolution test ; Carotenoid ; Non-everted rat intestinal sac model ; Intestinal permeation ; Food regulation ; Drug release ; USP apparatus II
- 刊名：Food Chemistry
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：210
- 期：Complete
- 页码：63-69
- 全文大小：586 K
文摘
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Lutein presents instability in sodium lauryl sulfate aqueous medium.
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Dissolution tests are an essential quality control tool for formulations containing lutein.
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Lutein’s apparent permeability coefficient of is similar to highly permeable substances.
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Lutein belongs in the class II of the biopharmaceutical classification system.