Dual-task-related neural connectivity changes in patients with Parkinson’ disease
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- 作者：G. Vervoorta ; griet.vervoort@faber.kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; E. Heremansa ; elke.heremans@faber.kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; A. Bengevoorda ; aniek.bengevoord@faber.kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; C. Strouwena ; carolien.strouwen@faber.kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; E. Nackaertsa ; evelien.nackaerts@faber.kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; W. Vandenbergheb ; wim.vandenberghe@uzleuven.be" class="auth_mail" title="E-mail the corresponding author ; A. Nieuwboera ; alice.nieuwboer@faber.kuleuven.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：CV ; coefficient of variability ; D ; dominant ; DT ; dual task ; FAB ; Frontal Assessment Battery ; FC ; functional connectivity ; FD ; framewise displacement ; FDR ; false discovery rate ; FOG ; freezing of gait ; GP ; globus pallidus ; MDS-UPDRS ; Movement Disorder Society-Unified Parkinson&rsquo ; s disease rating scale ; MFG ; middle frontal gyrus ; MMSE ; Mini-Mental State Examination ; MNI ; Montreal Neurological Institute ; MoCA ; Montreal Cognitive Assessment ; ND ; non-dominant ; NFOG-Q ; new freezing of gait question
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：11 March 2016
- 年：2016
- 卷：317
- 期：Complete
- 页码：36-46
- 全文大小：1224 K
文摘
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Motor control areas involved in dual-tasking show altered functional connectivity in patients with Parkinson’s disease.
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Hyper-connectivity involving the precuneus related to worse dual-task performance in freezers.
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Hypo-connectivity within the basal ganglia points to a role for dopamine depletion in dual-task impairment in freezers.
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Other functional connectivity patterns underscore executive impairment and loss of automaticity related to freezing of gait.