Role of nitric oxide in the radiation-induced bystander effect
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- 作者：Vasily A. Yakovlev ; vayakovlev@vcu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：BRCA1 ; breast cancer type 1 susceptibility protein ; Cav-1 ; caveolin 1 protein ; cGy ; centigray ; cNOS ; constitutive nitric oxide synthase ; c-PTIO ; 2-(4-carboxyphenyl)-4 ; 4 ; 5 ; 5-tetramethylimidazoline-1-oxyl-3-oxide ; DSB ; double-strand break ; E2F4 ; transcription factor E2F4 ; eNOS ; endothelial nitric oxide synthase ; GJIC ; gap junction intercellular communication ; GI ; genomic instability ; HRR ; homologous recombination repair ; iNOS ; inducible nitric oxide synthase ; l-NAME ; L-NG-nitroarginine methyl este
- 刊名：Redox Biology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：6
- 期：Complete
- 页码：396-400
- 全文大小：693 K
文摘
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Ionizing radiation stimulates generation of nitric oxide (NO).
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NO stimulates genomic instability by inhibiting BRCA1 protein expression.
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NO can diffuse and stimulate genomic instability in the bystander cells.
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Propagation of NO from cell-to-cell creates a class="boldFont">“mutator fields”.
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Definition of the class="boldFont">“mutator filed” is proposed.