Human papillomavirus 16 E2 interacts with neuregulin receptor degradation protein 1 affecting ErbB-3 expression in vitro and in clinical samples of cervical lesions
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- 作者：Francesca Paolinia ; b ; Gianfranca Curzioa ; b ; Elisa Meluccic ; Irene Terrenatod ; Barbara Antonianic ; Mariantonia Carosic ; Marcella Mottolesec ; Patrizia Vicie ; b ; Luciano Marianif ; b ; Aldo Venutia ; b ; 1 ; venuti@ifo.it" class="auth_mail" title="E-mail the corresponding author ; venutie4@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HPV ; E2 protein ; W12 cell line ; Nrdp-1 ; ErbB-3 ; Cervical cancer ; CIN ; IHC ; EGFR
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：52-61
- 全文大小：1873 K
文摘
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We showed epidermal growth factor receptor up- and ErbB-3 down-regulation in W12 cells after human papillomavirus (HPV) integration.
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HPV16 E2 interacts with the RING finger E3 ubiquitin ligase neuregulin receptor degradation protein 1 (Nrdp-1).
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E2/Nrdp-1 interaction renders ErbB-3 free to circulate to the cell membrane.
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Clinical samples with pure episomal HPV16 are highly positive for ErbB-3.
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Clinical samples with totally integrated HPV16 were negative for ErbB-3.