The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells
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- 作者：Giulia Chiaruttini1 ; Giulia M. Piperno1 ; Mabel Jouve2 ; Francesca De Nardi1 ; Paola Larghi3 ; 4 ; Andrew A. Peden5 ; Gabriele Baj6 ; Sabina Mü ; ller7 ; Salvatore Valitutti7 ; Thierry Galli8 ; 9 ; Federica Benvenuti1 ; benvenuti@icgeb.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：22 March 2016
- 年：2016
- 卷：14
- 期：11
- 页码：2624-2636
- 全文大小：4150 K
文摘
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Intracellular trafficking of IL-12 in dendritic cells is mediated by the SNARE VAMP7
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VAMP7 is required for optimal secretion of IL-12 in the extracellular space
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IL-12/VAMP7+ vesicles gather at the immune synapse
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VAMP7 controls synaptic release of IL-12 and IFN-γ production in T cells