Prime-boost therapeutic vaccination in mice with DNA/DNA or DNA/Fowlpox virus recombinants expressing the Human Papilloma Virus type 16 E6 and E7 mutated proteins fused to the coat protein of Potato virus X
详细信息 查看全文
- 作者：Elena Illianoa ; 1 ; elena.illiano@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Massimiliano Bissaa ; 1 ; 3 ; massimiliano.bissa@unimi.it" class="auth_mail" title="E-mail the corresponding author ; massimiliano.bissa@nih.gov" class="auth_mail" title="E-mail the corresponding author ; Francesca Paolinib ; francesca.paolini@ifo.gov.it" class="auth_mail" title="E-mail the corresponding author ; Carlo Zanottoc ; carlo.zanotto@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Carlo De Giuli Morghend ; e ; carlo.degiulimorghen@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Rosella Franconif ; rosella.franconi@enea.it" class="auth_mail" title="E-mail the corresponding author ; Antonia Radaellia ; d ; 2 ; antonia.radaelli@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Aldo Venutib ; 2 ; aldo.venuti@ifo.gov.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：HPV therapeutic vaccines ; Fowlpox virus recombinants ; Prime/boost immunizations ; Potato virus X coat protein ; E6 and E7 modified oncoproteins
- 刊名：Virus Research
- 出版年：2016
- 出版时间：2 October 2016
- 年：2016
- 卷：225
- 期：Complete
- 页码：82-90
- 全文大小：1131 K
文摘
- class="listitem" id="list_lis0005">
- class="label">•
FP-E6F47RCP and FP-E7GGGCP correctly express transgenes in different cell lines.
- class="label">•
After the genetic immunization, tumor volume was lower than in the control mice.
- class="label">•
Genetic immunization delayed tumor appearance compared to control mice.
- class="label">•
After DNA/FP vaccination, better results were obtained by E6/E7 single immunogens.