Disruption of the sigS gene attenuates the local innate immune response to Staphylococcus aureus in a mouse mastitis model
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- 作者：Vincent Petona ; b ; 1 ; Koen Breynec ; 1 ; Lucie Raulta ; b ; Kristel Demeyerec ; Nadia Berkovaa ; b ; Evelyne Meyerc ; Sergine Evena ; b ; Yves Le Loira ; b ; yves.leloir@rennes.inra.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Staphylococcus aureus ; Mastitis ; σ factor ; Transcriptional regulator ; Virulence ; Inflammatory response ; Mouse model
- 刊名：Veterinary Microbiology
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：186
- 期：Complete
- 页码：44-51
- 全文大小：932 K
文摘
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ThesigS gene was found disrupted in several S. aureus strains isolated from subclinical ovine mastitis.
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When disrupted the sigS gene did not affect S. aureus O11 in growth conditions mimicking mastitis.
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Although the mutant S. aureus ΔsigS induced similar clinical signs in experimental mastitis in a mouse model, the local immune response was milder in mice infected with S. aureus ΔsigS compared to those infected with the wild type strain.