Sonorheometry assessment of platelet function in cardiopulmonary bypass patients: Correlation of blood clot stiffness with platelet integrin αIIbβ3 activity, aspirin usage, and transfusion risk
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- 作者：Francesco Violaa ; fv7d@virginia.edu" class="auth_mail" title="E-mail the corresponding author ; Xiefan Lin-Schmidta ; XLinschm@its.jnj.com" class="auth_mail" title="E-mail the corresponding author ; Castigliano Bhamidipatib ; casti.bhamidipati@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Doris M. Haverstickc ; dmh2t@virginia.edu" class="auth_mail" title="E-mail the corresponding author ; William F. Walkera ; d ; bwalker@hemosonics.com" class="auth_mail" title="E-mail the corresponding author ; Gorav Ailawadib ; GA3F@hscmail.mcc.virginia.edu" class="auth_mail" title="E-mail the corresponding author ; Michael B. Lawrencea ; mbl2a@virginia.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：138
- 期：Complete
- 页码：96-102
- 全文大小：584 K
文摘
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Acoustic radiation force can be used to test blood clot stiffness in cardiac patients.
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Ex vivo clot stiffness tracked cardiopulmonary bypass patient overall hemostatic function closely.
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Platelet integrin αIIbβ3 function could be correlated with overall risk of perioperative transfusions with an ROC of 0.79.
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CPB patients on aspirin therapy had lower clot stiffness and lower indices of platelet adhesive function.