Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy
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- 作者：Chun-Yu Chen1 ; 8 ; Jee-Boong Lee1 ; 8 ; Bo Liu1 ; Shoichiro Ohta2 ; Pin-Yi Wang3 ; Andrey V. Kartashov1 ; Luke Mugge1 ; J. Pablo Abonia1 ; Artem Barski1 ; Kenji Izuhara4 ; Marc E. Rothenberg1 ; Fred D. Finkelman5 ; 6 ; 7 ; Simon P. Hogan1 ; Yui-Hsi Wang1 ; yui_hsi.wang@cchmc.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2015
- 出版时间：20 October 2015
- 年：2015
- 卷：43
- 期：4
- 页码：788-802
- 全文大小：5380 K
文摘
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Multi-functional MMC9s produce prodigious amounts of IL-9 and mast cell mediators
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MMC9 development increases in mice susceptible to IgE-mediated food allergy
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Induction of MMC9s requires T cells and IL-4, not IL-9, signals
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MMC9s amplify intestinal mastocytosis that drives IgE-mediated food allergy