OPRK1 promoter hypermethylation increases the risk of Alzheimer鈥檚 disease
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- 作者：Huihui Jia ; 1 ; Yunliang Wangb ; 1 ; wangyunliang81@163.com" class="auth_mail" title="E-mail the corresponding author ; Guili Liua ; 1 ; Xuting Xua ; Dongjun Daia ; Zhongming Chenc ; Dongsheng Zhouc ; Xiaohui Zhoud ; Liyuan Hana ; Ying Lie ; Renjie Zhuoa ; Qingxiao Honga ; Liting Jianga ; Xiaonan Zhanga ; Yu Liua ; Lei Xua ; Lan Changa ; Jinfeng Lib ; Pengyuan Ana ; Shiwei Duana ; duanshiwei@nbu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Qinwen Wanga ; wangqinwen@nbu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer disease ; DNA methylation ; Promoter ; OPRK1 ; Expression
- 刊名：Neuroscience Letters
- 出版年：2015
- 出版时间：8 October 2015
- 年：2015
- 卷：606
- 期：Complete
- 页码：24-29
- 全文大小：1169 K
文摘
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OPRK1 is a member of the opioid family and plays an important role in cognitive and learning functions.
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The levels of DNA methylation of OPRK1 promoter CpG sites were significantly higher in Alzheimer disease patients than controls.
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OPRK1 promoter hypermethylation may increase the risk of AD.