Spiromastilactone A-M were isolated as new polyketides from a deep-sea fungus Spiromastix sp.
Spiromastilactone D exerted potent inhibitory activity against WSN influenza virus.
Spiromastilactone D inhibited a panel of drug resistant clinical isolates.
Spiromastilactone D synergistically targeted hemagglutinin and RNP complexes to disrupt the viral entry and replication.