Peptide receptor radionuclide therapy of neuroendocrine tumours

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• 作者：Tessa Brabander ; MD^a ; ^{t.brabander@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} (PhD-student) ; Jaap J.M. Teunissen ; MD ; PhD^a ; ^{j.teunissen@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} (Nuclear Medicine Physician) ; Casper H.J. Van Eijck ; MD ; PhD^b ; ^{c.vaneijck@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} (Surgeon) ; Gaston J.H. Franssen ; MD^b ; ^{g.franssen@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} (Surgeon) ; Richard A. Feelders ; MD ; PhD^c ; ^{r.feelders@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} (Endocrinologist) ; Wouter W. de Herder ; MD ; PhD^c ; ^{w.w.deherder@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} (Endocrinologist) ; Dik J. Kwekkeboom ; MD ; PhD^a ; ^{d.j.kwekkeboom@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author} (Nuclear Medicine Physician)
• 关键词：neuroendocrine tumours ; PRRT ; radionuclides ; somatostatin receptor
• 刊名：Best Practice Research Clinical Endocrinology Metabolism
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：30
• 期：1
• 页码：103-114
• 全文大小：494 K

文摘

In the past decades, the number of neuroendocrine tumours that are detected is increasing. A relative new and promising therapy for patients with metastasised or inoperable disease is peptide receptor radionuclide therapy (PRRT). This therapy involves an infusion of somatostatin analogues linked to radionuclides like Yttrium-90 or Lutetium-177. Objective response rates are reported in 15–35%. Response rates may vary between type of tumour and radionuclide. Besides the objective response rate, overall survival and progression free survival increase significantly. Also, the quality of life improves as well. Serious side-affects are rare. PRRT is usually well tolerated, also in patients with extensive metastasised disease. Recent studies combined PRRT with other types of therapies. Unfortunately no randomised trials comparing these strategies are available. In the future, more research is needed to evaluate the best therapy combinations or sequence of therapies.