An integrin beta4-EGFR unit promotes hepatocellular carcinoma lung metastases by enhancing anchorage independence through activation of FAK-AKT pathway
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- 作者：Chao Leng ; Zhan-guo Zhang ; Wei-xun Chen ; Hong-ping Luo ; Jia Song ; Wei Dong ; Xuan-ru Zhu ; Xiao-ping Chen ; Hui-fang Liang ; lianghuifang1997@126.com" class="auth_mail" title="E-mail the corresponding author ; Bi-xiang Zhang ; bixiangzhang@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatocellular carcinoma ; Anoikis ; Integrin beta4 ; Metastases ; EGFR
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 June 2016
- 年：2016
- 卷：376
- 期：1
- 页码：188-196
- 全文大小：3076 K
文摘
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ITGB4 is overexpressed in HCC tissues and aggressive HCC cells and associated with HCC metastases.
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The ITGB4–EGFR unit promotes anchorage independence by activating AKT signaling pathway.
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The ITGB4–EGFR unit triggers the FAK rather than SRC to activate AKT pathway.
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ITGB4 enhances tumor growth and pulmonary metastases of HCC in vivo.