Chlorogenic acid ameliorates endotoxin-induced liver injury by promoting mitochondrial oxidative phosphorylation
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- 作者：Yan Zhoua ; b ; Zheng Ruana ; ruanzheng@ncu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Lili Zhoua ; Xugang Shua ; Xiaohong Sunb ; Shumei Mia ; Yuhui Yanga ; Yulong Yina ; c ; yinyulong@isa.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chlorogenic acid ; Hepatoprotective ; Energy metabolism ; Glycolysis ; Mitochondrial respiration
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：22 January 2016
- 年：2016
- 卷：469
- 期：4
- 页码：1083-1089
- 全文大小：1031 K
文摘
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Dietary supplementation with chlorogenic acid (CGA) improved endotoxin-induced liver injury.
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Chlorogenic acid enhances ATP increase and shifts energy metabolism, which is correlated with up-regulation AMPK and PGC-1α.
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The possible mechanism of CGA on mitochondrial biogenesis was correlated with up-regulation AMPK and PGC-1α.