Up-regulated ephrinB3/EphB3 expression in intractable temporal lobe epilepsy patients and pilocarpine induced experimental epilepsy rat model
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- 作者：Hao Huang ; Ruohan Li ; Jinxian Yuan ; Xin Zhou ; Xi Liu ; Shu Ou ; Tao Xu ; Yangmei Chen ; chenym1997@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AEDs ; anti-epileptic drugs ; AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid ; cDNA ; complementary DNA ; CNS ; central nervous system ; DAB ; 3 ; 3-diaminobenzidine ; DAPI ; 4 ; 6-diamidino-2-phenylindole ; EEG ; electroencephalogram ; GPI ; glycosyl phosphatidylinositol ; IE ; intractable epilepsy ; ILAE ; International League Against Epilepsy ; i.p. ; intraperitoneal ; LiCl ; lithium chloride ; MAP2 ; microtubule-associated protein 2 ; OD ; optical density ; PBS ; phosphate buffered saline ; RTKs ; receptor tyros
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：1639
- 期：Complete
- 页码：1-12
- 全文大小：9335 K
文摘
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Abnormal ephrinBs and EphBs mRNA expression were observed in patients and rats with intractable temporal lobe epilepsy (TLE).
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ephrinB3 and EphB3 were up-regulated in intractable TLE patients and rats.
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ephrinB3 located in both glia and neurons, EphB3 located in neurons.
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ephrinB3 and EphB3 may serve as potential biomarkers for predicting TLE.