Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model
详细信息 查看全文
- 作者：Jingquan Gaoa ; b ; Xuelai Wanga ; Hongli Sunc ; Yonggang Caoc ; Shuang Lianga ; Han Wanga ; Yanming Wangd ; Feng Yange ; Fengyu Zhange ; 1 ; zhangf28@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Lijie Wua ; 1 ; wljhyd@ems.hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; wulijiehyd@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Docosahexaenoic acid (DHA) ; Autism ; Neuroprotective ; Hippocampal cell ; Learning impairment ; Memory impairment
- 刊名：International Journal of Developmental Neuroscience
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：49
- 期：Complete
- 页码：67-78
- 全文大小：3285 K
文摘
- class="listitem" id="list_lis0005">
- class="label">•
We evaluated the impacts of DHA in an experimental rat autism model.
- class="label">•
DHA increased the levels of hippocampal p-CaMKII and p-CREB.
- class="label">•
DHA altered BDNF-AKT-Bcl-2 signalling pathway and inhibited the activity of caspase-3.
- class="label">•
DHA influenced the content of malondialdehyde (MDA) and the activities of antioxidant enzymes.
- class="label">•
DHA improved dysfunctional locomotors activity and prevented cognitive impairment.