Subchronic toxicity study of the total flavonoids from Rosa laevigata Michx fruit in rats

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• 作者：Shuai Zhang^a ; ¹ ; Lingli Zheng^b ; ¹ ; Lina Xu^a ; Huijun Sun^a ; Hua Li^a ; Jihong Yao^a ; Kexin Liu^a ; Jinyong Peng^a ; ^{jinyongpeng2005@163.com}
• 关键词：Natural product ; NOAEL ; Rosa laevigata Michx ; Total flavonoids ; 90-day subchronic toxicity
• 刊名：Regulatory Toxicology and Pharmacology
• 出版年：2012
• 出版时间：March, 2012
• 年：2012
• 卷：62
• 期：2
• 页码：221-230
• 全文大小：2275 K

文摘

The total flavonoids (TFs) from Rosa laevigata Michx fruit showed hepatoprotective and antioxidant activities. However, the safety of this natural product has not been investigated. In the present paper, a 90-day subchronic toxicity study was conducted, and the tested TFs was orally administered to rats at the doses of 500, 1000 and 2000 mg/kg/day. The toxicity of the TFs was evaluated on base of ophthalmic examination, body weight, feed/water consumption, urinalysis, hematology, clinical biochemistry and pathology. No toxic signs of the TFs at the doses of 500 and 1000 mg/kg/day were observed. However, decreased PLT was found in the 2000 mg/kg/day groups and increased intercellular space of myocardial cells was observed in the male 2000 mg/kg/day group compared with control. A significant increase in the relative cardiac weight was observed in the male 1000 and 2000 mg/kg/day groups. And the significant decrease in the absolute and relative weight of adrenals in the female 1000 and 2000 mg/kg groups was happened. The TFs could cause mild side effects at the dose of 1000 mg/kg/day in males and females. Thus, the dose of 500 mg/kg/day for male and female were selected as the no-observed-adverse-effect level (NOAEL). The present study provides useful data for subsequent researches and new drug exploration of the TFs from R. laevigata Michx fruit.