Long-term follow-up after radio-frequency catheter-based denervation in patients with resistant hypertension

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• 作者：Mariusz Skowerski ; ^{mskowerski@yahoo.co.uk" class="auth_mail" title="E-mail the corresponding author} ; Tomasz Roleder ^{tomaszroleder@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Katarzyna Bańska-Kisiel ^{kasiabanska@op.pl" class="auth_mail" title="E-mail the corresponding author} ; Piotr Pysz ^{piotr.pysz@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Andrzej Ochała ^{aochala@poczta.onet.pl" class="auth_mail" title="E-mail the corresponding author} ; Wojciech Wojakowski ^{wojtek.wojakowski@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Zbigniew Gąsior ^{zbgasior@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Resistant-hypertension ; Renal denervation ; Catheter based renal sympathetic denervation
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 July 2016
• 年：2016
• 卷：215
• 期：Complete
• 页码：472-475
• 全文大小：192 K

文摘

The aim of this single-center study was to asses the long-term clinical data of patients with resistant hypertension who underwent radiofrequency renal denervation (RND).

Methods

Out of 86 patients with resistant-hypertension, 15 pts fulfilled the study criteria for performing RND using Simplicity system by Medtronic.

Results

Baseline office systolic BP was 204 ± 32.7 and diastolic BP 107.7 ± 15.1 mm Hg. Baseline 24 h ambulatory systolic BP was 151.8 ± 13.9 and diastolic BP 86.8 ± 13.8 mm Hg. Patients were treated with an average of 5 antihypertensive agents in maximally tolerated doses (including diuretic) during the whole trial and were followed up at 1,6,24 month after RND. At every appointment an echocardiography, blood test, and blood pressure (office and ABMP) measurements were performed. The mean reduction in office systolic (SBP) and diastolic (DBP) blood pressure were the following:

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1 month after RND − 39 (± 28.6)/− 15 (± 12.8) mm Hg.

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6 months after RND − 47 (± 29.14)/− 22 (± 13.26) mm Hg.

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24 months after RND − 49 (± 37.7)/− 20 (± 11.5) mm Hg.

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The mean reduction in 24 h ambulatory systolic (SBP) and diastolic (DBP) blood pressure were the following:

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1 month after RND − 7.4 (± 16.4)/− 8.7 (± 22.05) mm Hg.

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6 months after RND − 11.3 (± 16.1)/− 9.5 (± 19.15) mm Hg.

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24 months after RND − 9.6 (± 16.3)/− 7.9 (± 15.03) mm Hg.

There were no procedural complications. All denervations were performed by experienced operator.

Conclusions

We regard RND as a safe and effective procedure in resistant hypertension, although more studies and trials are needed to find the most adequate model of a patient that would be a good responder to RND.