Loss of PINK1 inhibits apoptosis by upregulating α-synuclein in inflammation-sensitized hypoxic-ischemic injury in the immature brains
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- 作者：Jianghu Zhua ; b ; c ; zhujianghu2005@163.com" class="auth_mail" title="E-mail the corresponding author ; Yi Qua ; b ; quyi712002@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhenlang Linc ; linzhenlang@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Fengyan Zhaoa ; b ; hanyue80@163.com" class="auth_mail" title="E-mail the corresponding author ; Li Zhanga ; b ; zhanglihk@126.com" class="auth_mail" title="E-mail the corresponding author ; Yang Huanga ; b ; 1027996742@qq.com" class="auth_mail" title="E-mail the corresponding author ; Changan Jianga ; b ; cjcareer@qq.com" class="auth_mail" title="E-mail the corresponding author ; Dezhi Mua ; b ; d ; dezhi.mu@ucsf.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PINK1 ; PTEN-induced putative kinase 1 ; α-Syn ; α-synuclein ; LPS ; lipopolysaccharide ; CP ; cerebral palsy ; HI ; hypoxia-ischemia ; TTC ; 2 ; 3 ; 5-triphenyltetrazolium chloride ; TUNEL ; TdT-mediated dUTP nick end-labeling ; CC3 ; cleaved caspase-3 ; siRNA ; small interfering RNA
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 December 2016
- 年：2016
- 卷：1653
- 期：Complete
- 页码：14-22
- 全文大小：994 K
文摘
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Inflammation sensitizes hypoxic-ischemic injury in the immature brain.
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Loss of PINK1 protects the immature brain against cell apoptosis induced by inflammation-sensitized hypoxic-ischemic injury.
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α-Synuclein plays a neuroprotective role in inflammation-sensitized hypoxic-ischemic brain damage in PINK1-knockout neonatal mice.