CRISPR/Cas9 produces anti-hepatitis B virus effect in hepatoma cells and transgenic mouse
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- 作者：Wei Zhu ; zhuwei8247@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Kun Xie ; Yuanjian Xu ; Le Wang ; Kaiming Chen ; Longzhen Zhang ; Jianmin Fang ; jfang@Tongji.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CRISPR/Cas9 ; HBV ; cccDNA ; Hydrodynamics
- 刊名：Virus Research
- 出版年：2016
- 出版时间：2 June 2016
- 年：2016
- 卷：217
- 期：Complete
- 页码：125-132
- 全文大小：2479 K
文摘
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Two homologous sequences of HBV specific CRISPR/Cas9 systems were constructed.
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The pCas9-2 produces better anti-HBV effects of in vitro and in vivo model.
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The designed CRISPR/Cas9 system can provide a potential strategy for curing chronic HBV infection.