Letter to the Editor regarding Bajaj D, et al., The resistance of cortical bone tissue to failure under cyclic loading is reduced with alendronate, Bone 2014;64:57-64
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Experimental data were excluded from analyses of effects of alendronate treatment on fatigue life of bone specimens from canine ribs.

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We specify why the exclusion criteria were inappropriate.

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Exclusion of these data changed statistically insignificant results to significant results for certain comparisons.

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An additional one third of include tests stopped prior to complete failure, but these data were not analyzed ascensored data.

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Modulus loss did not show any treatment effect whether all of the data or only selected data are considered.

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