Increased prevalence of autoimmune phenomena in myelofibrosis: Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns

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• 作者：Wilma Barcellini ; Aless ; ra Iurlo ; Tommaso Radice ; Francesca Guia Imperiali ; Anna Zaninoni ; Bruno Fattizzo ; Francesca Guidotti ; Paola Bianchi ; Elisa Fermo ; Dario Consonni ; Agostino Cortelezzi
• 关键词：Myelofibrosis ; Cytokines ; Autoimmunity
• 刊名：Leukemia Research
• 出版年：November, 2013
• 年：2013
• 卷：37
• 期：11
• 页码：1509-1515
• 全文大小：777 K

文摘

Autoimmune phenomena and cytokines were investigated in 100 patients with myelofibrosis (MF) and related to marrow fibrosis and clinical risk. Anti-erythrocyte antibodies by mitogen-stimulated direct antiglobulin test (MS-DAT) were positive in 45%, anti-platelets in 15% and organ/non organ-specific in 57% of cases, without clinically overt disease, and mostly in low-risk/intermediate-risk-1 and MF-0/MF-1. TGF-尾 and IL-8 were increased in MS-DAT positive cases, and IFN-纬 in patients with serological autoantibodies. TGF-尾 and IL-17 were elevated in early clinical and morphological stages, while IL-8 increased in advanced stages. These data suggest that autoimmune phenomena and cytokine disregulation are particularly relevant in early MF.