2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) role in hematopoiesis and in hematologic diseases: A critical review

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• 作者：Nicola Stefano Fracchiolla ; MD^a ; ^{n.fracchiolla@policlinico.mi.it} ; Claudio Annaloro^a ; Francesca Guidotti^a ; Bruno Fattizzo^a ; Agostino Cortelezzi^a ; ^b
• 关键词：TCCD ; tetrachlorodibenzo-p-dioxin ; PCDD ; polychlorinated dibenzodioxins ; AHR ; aryl hydrocarbon receptor ; Hsp90 ; heat shock protein 90 ; MAPK ; mitogen-activated protein kinase ; ARNT ; aryl hydrocarbon receptor nuclear translocator ; NF-kB ; nuclear factor kB ; CFU-C ; colonies forming unit cells ; LSK ; Lin&minus ; Sca-1+c-Kit+ cells ; BP ; benzo(a)pyrene ; Tetra CB ; tetrachlorobiphenyl ; SR1 ; stemregenin 1 ; STS ; soft tissue sarcomas ; NHL ; non Hodgkin lymphoma ; MM ; multiple myeloma ; HL ; Hodgkin lymphoma
• 刊名：Toxicology
• 出版年：2016
• 出版时间：30 December 2016
• 年：2016
• 卷：374
• 期：Complete
• 页码：60-68
• 全文大小：687 K
• 卷排序：374

文摘

Dioxin exposure and its effect on hematopoiesis and cancer have been largely investigated in both human and non-human settings. Here we systematically reviewed literature to address the question of what we know about TCDD biology and exposure. Most effects are due to TCDD interaction with a receptor of xenobiotics called AHR, which is ubiquitously represented and also works on hematopoietic myeloid and lymphoid stem cells, inducing proliferation and stem cell release from bone marrow to peripheral circulation. Epidemiologic studies on TCDD exposure demonstrated an association with onco-hematologic diseases, particularly with non Hodgkin lymphomas and multiple myeloma, and non hematologic cancers, such as sarcomas, although these relationships are affected by multiple confounding factors.