Nicotine enhances GABAergic inhibition of oxytocin mRNA-expressing neuron in the hypothalamic paraventricular nucleus in vitro in rats

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• 作者：Ke-Min Zhang^a ; ^b ; ¹ ; Guo-Yan Zhao^c ; ¹ ; Bin-Bin Zhang^a ; ^b ; Qi Xu^a ; Chun-Ping Chu^a ; Hua Jin^d ; ^{kimhua@ybu.edu.cn} ; De-Lai Qiu^a ; ^b ; ^{dlqiu@ybu.edu.cn} ; ^{dlqiu_neuron@hotmail.com} ;
• 关键词：ACSF ; artificial cerebrospinal fluid ; GABA ; gamma-aminobutyric acid ; PVN ; paraventricular nucleus ; CRH ; corticotropin-releasing hormone ; OT ; oxytocin ; sIPSPs ; spontaneous inhibitory postsynaptic potentials
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：638
• 期：Complete
• 页码：5-11
• 全文大小：2646 K
• 卷排序：638

文摘

Nicotine inhibited PVN OT-mRNA expressing neuron in a dose-dependent manner. GABAA blocker abolished the nicotine-induced inhibition of OT neuron. Nicotine increased sIPSPs frequency of OT-mRNA expressing neurons. Nicotine modulated PVN OT secretion via enhancement of presynaptic GABA release.