Cortisol levels in hair are altered in irritable bowel syndrome - A case control study in primary care

详细信息    查看全文

• 作者：A.-K. Norlin^a ; ^{anna-karin.norlin@liu.se} ; S. Walter^b ; E. Theodorsson^c ; V. Tegelstrom^d ; E. Grodzinsky^e ; ^f ; M.P. Jones^g ; Å ; . Faresjö ; ^a
• 关键词：Irritable bowel syndrome ; Stress ; Cortisol in hair ; HPA-axis ; Primary care
• 刊名：Journal of Psychosomatic Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：93
• 期：Complete
• 页码：69-75
• 全文大小：520 K
• 卷排序：93

文摘

What is current knowledge? Stress is an important component in the pathophysiology of Irritable Bowel Syndrome (IBS). Long term hypothalamic-pituitary-adrenal (HPA)-axis activity can be studied by measuring cortisol in hair. What is new? Low concentrations of cortisol in hair were more common in IBS patients compared to non-IBS patients. Self-reported perceived stress was higher in IBS patients compared to non-IBS patients. Our findings reveals a possible suppression of the HPA-axis activity in a considerable proportion of IBS patients.