Th2/Th3 cytokine genotypes are associated with pregnancy loss

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• 作者：Costeas ; Paul A. ; Koumouli ; Anita ; Giantsiou-Kyriakou ; Alina ; Papaloizou ; Andri ; Koumas ; Laura
• 关键词：cytokine gene polymorphisms ; immunogenetic profile ; abortion ; Th1/Th2/Th3
• 刊名：Human Immunology
• 出版年：2004
• 出版时间：February, 2004
• 年：2004
• 卷：65
• 期：2
• 页码：135-141
• 全文大小：247 K

文摘

Cytokines are critical immunoregulatory molecules, responsible for determining the nature of an immune response. It has been proposed that Th2/Th3 immune reactions support normal pregnancy, while Th1 immunity is considered detrimental to the fetus. Since cytokine production is partly under genetic control, it is possible that women suffering from a high incidence of abortions are genetically predisposed to mount a type of immune response inappropriate for pregnancy maintenance. This study investigated the frequencies of cytokine gene polymorphisms in abortion-prone women and women with successful pregnancies. We investigated the role of Th1/Th2/Th3 cytokine gene polymorphisms, such as TGF-β1 codon 10 (TGFβc10; C to T), TGF-β1 codon 25 (TGFβc25; G to C), TNFα promoter–308 (G to A), IL-6 promoter–174 (G to C), IL-10 promoter–1082 (G to A), IL-10 promoter–819 (C to T), IL-10 promoter–592 (C to A), and IFNγ intron 1 +874 (A to T) in abortion-prone female patients. Our results support the importance of Th2/Th3 immune responses in pregnancy loss, and suggest that an individual's immunogenetic profile indicative of imbalances in Th2/Th3 cytokines is associated with pregnancy loss. Our results suggest that abortive events are determined by genetic factors, reflected in the female patient's immunogenetic profile.