Costimulation Engages the Gear in Driving CARs

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• 作者：Hinrich Abken¹ ; ^{hinrich.abken@uk-koeln.de" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Immunity
• 出版年：2016
• 出版时间：16 February 2016
• 年：2016
• 卷：44
• 期：2
• 页码：214-216
• 全文大小：840 K

文摘

In this issue of Immunity, Kawalekar et al. (2016) find that costimulation by a chimeric antigen receptor (CAR) can control T cell metabolism and balance the response toward long-lived memory or short-lived effector cells. The results provide a rationale of how to tune cancer immunotherapy more effectively in a hostile tumor environment.