T cell costimulation blockade for hyperacute steroid refractory graft versus-host disease in children undergoing haploidentical transplantation
详细信息 查看全文
- 作者：Sarita Rani Jaiswala ; b ; drsaritaranij@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Shamsuz Zamanb ; Aditi Chakrabartia ; Amit Sehrawatb ; Satish Bansalb ; Mahesh Guptab ; Suparno Chakrabartia ; b
- 关键词：Haploidentical ; Costimulation blockade ; GVHD ; Steroid-refractory ; Pediatric
- 刊名：Transplant Immunology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：39
- 期：Complete
- 页码：46-51
- 全文大小：340 K
文摘
- •
The outcome of hyperacute grade 3-4 steroid-refractory graft-versus-host-disease (SR-GVHD) following haploidentical HSCT is dismal.
- •
The replacement of ATG with Abatacept seemed to produce encouraging early response and might warrant further investigation.
- •
Sirolimus in combination with Abatacept might improve recovery of T regulatory cells and result in sustained response.