Odontoblast primary cilia: facts and hypotheses

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• 作者：Magloire ; Henry ; Couble ; Marie-Lise ; Romeas ; Annick ; Bleicher ; Franç ; oise
• 关键词：Tooth ; Odontoblast ; Cilium ; Ion channels ; Calbindin D28k
• 刊名：Cell Biology International
• 出版年：2004
• 出版时间：2004
• 年：2004
• 卷：28
• 期：2
• 页码：93-99
• 全文大小：944 K

文摘

Odontoblasts, the cells responsible for the dentine formation, are organized as a single layer of highly polarized and differentiated post-mitotic cells along the interface between the dental pulp and the mineralized tubules. They lay down the physiological secondary dentine throughout the life of the teeth. Odontoblasts play a central role in the transportation of calcium to the dentine and they possibly mediate early stages of sensory processing in teeth. A primary cilium, 9+0 configuration, have been regularly identified in a supra nuclear location. Calbindin D28k has been detected at the base of the cilium membrane. The cilium structure was positive with detyrosinated α tubulin antibodies in vivo and in cultured human odontoblasts. Transcripts of tektin, a protein involved in ciliogenesis, were expressed in vitro. The putative role of the primary cilium constituting a critical link between external teeth stimuli and odontoblast responses is extensively discussed.