Active Transport of an Antibiotic Rifamycin Derivative by the Outer-Membrane Protein FhuA

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• 作者：Ferguson ; Andrew D. ; Kö ; dding ; Jiri ; Walker ; Georg ; Bö ; s ; Christoph ; Coulton ; James W. ; et. al.
• 关键词：active transport ; antibiotic ; crystal structure ; structure-based drug design ; TonB-dependent transporter ; integral membrane protein
• 刊名：Structure
• 出版年：2001
• 出版时间：August, 2001
• 年：2001
• 卷：9
• 期：8
• 页码：707-716
• 全文大小：311 K

文摘

Background: FhuA, an integral membrane protein of Escherichia coli, actively transports ferrichrome and the structurally related antibiotic albomycin across the outer membrane. The transport is coupled to the proton motive force, which energizes FhuA through the inner-membrane protein TonB. FhuA also transports the semisynthetic rifamycin derivative CGP 4832, although the chemical structure of this antibiotic differs markedly from that of ferric hydroxamates.