Coordinated Rearrangements between Cytoplasmic and Periplasmic Domains of the Membrane Protein Complex ExbB-ExbD of Escherichia coli
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- 作者：Aleksandr Sverzhinsky1 ; Lucien Fabre2 ; Andrew L. Cottreau1 ; Damien M.P. Biot-Pelletier1 ; Sofia Khalil1 ; 5 ; Mihnea Bostina3 ; 6 ; Isabelle Rouiller2 ; James W. Coulton1 ; 4 ; james.coulton@mcgill.ca" class="auth_mail
- 刊名：Structure
- 出版年：6 May 2014
- 年：2014
- 卷：22
- 期：5
- 页码：791-797
- 全文大小：1276 K
文摘
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Membrane proteins ExbB and ExbD form a complex of 4:2 stoichiometry
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The protein-detergent complex is ∼240 kDa: ∼140 kDa protein + ∼100 kDa DDM
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2D EM analyses reveal structural diversity despite biochemical homogeneity
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3D reconstructions show different structural states and coordinated rearrangement