Anti-Ku antibodies: Clinical, genetic and diagnostic insights

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• 作者：C. Belizna ; D. Henrion ; A. Beucher ; C. Lavigne ; A. Ghaali ; H. Lé ; vesque
• 刊名：Autoimmunity Reviews
• 出版年：2010
• 出版时间：August 2010
• 年：2010
• 卷：9
• 期：10
• 页码：691-694
• 全文大小：171 K

文摘

Anti-Ku antibodies are reported in various connective tissue diseases and the Ku complex can be responsible for a very strong autoimmune answer in autoimmune disease. Nowadays, anti-Ku antibodies are detected by ELISA, counterimmunoelectrophoresis (CIE), immunoblot (IB) and new highly performant techniques.

Although the prevalence of anti-Ku antibodies is not homogenous, depending on several features such as disease type, genetic and geographical clustering, and also method of detection, they could be found in 55 % overlap PM/systemic sclerosis patients.

Moreover, anti-Ku antibodies are not associated with a particular clinical outcome, and especially with cancer related to myositis.