Diastereoselective synthesis of the 5-hydroxy-pyrrolidinone amino acid of the microsclerodermins and model studies for an end-game strategy for microsclerodermin B

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• 作者：Christian Winter ; Robert D.C. Pullin ; Timothy J. Donohoe ; ^{timothy.donohoe@chem.ox.ac.uk}
• 关键词：Amino acids ; Cyclic peptides ; Stereoselective synthesis ; Peptide coupling ; Metathesis
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：58
• 期：7
• 页码：602-605
• 全文大小：819 K
• 卷排序：58

文摘

Diastereoselective synthesis of amino acids from the microsclerodermins. A pyrrolidinone amino acid was made by alkene hydration in two steps. Bromination and dehalogenation gives a sensitive hemiaminal amino acid.