Diterpenes and sesquiterpenes with anti-Coxsackie virus B3 activity from the stems of Illicium jiadifengpi

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• 作者：Gui-Jie Zhang^a ; Yu-Huan Li^b ; Jian-Dong Jiang^a ; ^b ; Shi-Shan Yu^a ; ^{yushishan@imm.ac.cn" class="auth_mail} ; ^{yushishan_imm@163.com" class="auth_mail} ; Xiao-Jing Wang^a ; Peng-Yu Zhuang^a ; Yan Zhang^a ; Jing Qu^a ; Shuang-Gang Ma^a ; Yong Li^a ; Yun-Bao Liu^a ; De-Quan Yu^a
• 关键词：Illicium jiadifengpi ; Stems ; Diterpenes ; Sesquiterpenes ; Anti-Coxsackie virus B3
• 刊名：Tetrahedron
• 出版年：29 July 2014
• 年：2014
• 卷：70
• 期：30
• 页码：4494-4499
• 全文大小：494 K

文摘

Seven new diterpenes, jiadifenoic acids J–P (1–7), two new sesquicarane sesquiterpenes, sesquicaranoic acids A and B (8 and 9), and four known compounds, were isolated from the stems of Illicium jiadifengpi. The trans-fused A/B ring junction in diterpenes was deduced from NMR data analysis and confirmed by single-crystal X-ray crystallography of 3. The absolute configurations of compounds 1 and 5 were determined using the Mo₂(OAc)₄-induced circular dichroism (ICD) method. Compounds 8 and 9 are a pair of C-10 epimers, and their absolute configurations were confirmed by analyzing their CD and ICD data. All of the isolated compounds were evaluated in vitro for their antiviral activities against Coxsackie virus B3 (CVB3). Among the isolated compounds, 4, 5, 7, 10, and 11 exhibited reasonable activity against CVB3, with IC₅₀ values of 7.0–22.2 渭mol/mL and selective index values (SI=TC₅₀/IC₅₀) of 49.3, 37.1, 31.3, 45.6 and 40.9, respectively.