A review on controlled porosity osmotic pump tablets and its evaluation

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• 作者：Chinmaya Keshari Sahoo^a ; ^{Id-sahoo.chinmaya83@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Nalini Kanta Sahoo^b ; Surepalli Ram Mohan Rao^c ; Muvvala Sudhakar^d ; Kokkula Satyanarayana^e
• 关键词：Osmotic drug delivery system ; Osmosis ; CPOP ; Microporous ; Zero order
• 刊名：Bulletin of Faculty of Pharmacy, Cairo University
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：53
• 期：2
• 页码：195-205
• 全文大小：496 K

文摘

Conventional drug delivery system provides an immediate release of drug which does not control the release of the drug and does not maintain effective concentration at target site for a longer period of time. Hence to avoid the shortcomings there is development of various controlled drug delivery systems. Among these osmotic drug delivery system (ODDS) utilizes the principle of osmotic pressure and delivers drug dose in an optimized manner to maintain drug concentration within the therapeutic window and minimizes toxic effects. ODDS releases drug at a controlled rate that is independent of the pH and thermodynamics of dissolution medium. The release of drug from ODDS follows zero order kinetics. The release of drug from osmotic system depends upon various formulation factors such as solubility, osmotic pressure of the core components, size of the delivery orifice and nature of the rate controlling membrane. Controlled porosity osmotic pump (CPOP) contains drug, osmogens, excipients in core and a coating of semipermeable membrane with water soluble additives. In CPOP water soluble additives dissolve after coming in contact with water, resulting in an in situ formation of a microporous membrane. The present study gives an idea about osmosis, CPOP, components of CPOP and its evaluation.