Fatty acid oxidation is required for de novo synthesis of nucleotides in endothelial cell, thus functional angiogenesis.

The importance of other aspects of endothelial fatty acid metabolism requires further detailed investigation.

Cancer fatty acid metabolism is required for survival and growth and to overcome periods of metabolic stress.

In cancer cells ATP and NADPH derived from fatty acid oxidation enable protection from ROS and energy maintenance.

Fatty acid oxidation is a potential target for anti-angiogenic therapies in cancer.