A one-pot, multi-component reaction cascade for the rapid synthesis of diversely functionalized heteroaryl methyl substrates

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• 作者：Daniel E. Jeffries^a ; Craig W. Lindsley^a ; ^b ; ^{craig.lindsley@vanderbilt.edu}
• 关键词：Suzuki-Miyaura coupling ; Sonogashira coupling ; Multi-component ; Heterocyclic chemistry
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：58
• 期：1
• 页码：112-116
• 全文大小：635 K
• 卷排序：58

文摘

A one-pot, multi-component reaction cascade for the rapid synthesis of diversely functionalized heteroaryl methyl substrates. A tandem SN2/Suzuki-Miyaura reaction with yields ranging between 50 and 66% A tandem SN2 Sonogashira reaction across a breadth of chemical diversity with yields ranging between 31 and 87% Rapid access to biologically relevant molecules.