Bioabsorbable bone plates enabled with local, sustained delivery of alendronate for bone regeneration

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• 作者：Woojune Hur^a ; ^b ; ¹ ; Min Park^c ; ¹ ; Jae Yeon Lee^c ; Myung Hun Kim^c ; Seung Ho Lee^c ; Chun Gwon Park^d ; Se-Na Kim^c ; Hye Sook Min^e ; Hye Jeong Min^a ; ^b ; Jin Ho Chai^f ; Sang Jeong Lee^g ; Sukwha Kim^b ; Tae Hyun Choi^b ; ^{psthchoi@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Young Bin Choy^c ; ^d ; ^g ; ^{ybchoy@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Alendronate ; Bioabsorbable bone plate ; Bone regeneration ; Drug delivery
• 刊名：Journal of Controlled Release
• 出版年：2016
• 出版时间：28 January 2016
• 年：2016
• 卷：222
• 期：Complete
• 页码：97-106
• 全文大小：1368 K

文摘

We prepared a bone plate enabled with the local, sustained release of alendronate, which is a drug known to inhibit osteoclast-mediated bone resorption and also expedite the bone-remodeling activity of osteoblasts. For this, we coated a bone plate already in clinical use (PLT-1031, Inion, Finland) with a blend of alendronate and a biocompatible polymer, azidobenzoic acid-modified chitosan (i.e., Az-CH) photo-crosslinked by UV irradiation. As we performed the in vitro drug release study, the drug was released from the coating at an average rate of 4.03 μg/day for 63 days in a sustained manner. To examine the effect on bone regeneration, the plate was fixed on an 8 mm cranial critical size defect in living rats and the newly formed bone volume was quantitatively evaluated by micro-computed tomography (micro-CT) at scheduled times over 8 weeks. At week 8, the group implanted with the plate enabled with sustained delivery of alendronate showed a significantly higher volume of newly formed bone (52.78 ± 6.84%) than the groups implanted with the plates without drug (23.6 ± 3.81%) (p < 0.05). The plate enabled with alendronate delivery also exhibited good biocompatibility on H&E staining, which was comparable to the Inion plate already in clinical use. Therefore, we suggest that a bone plate enabled with local, sustained delivery of alendronate can be a promising system with the combined functionality of bone fixation and its expedited repair.