ADAM10 is essential for cranial neural crest-derived maxillofacial bone development
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- 作者：Yu Tan tanyu2048@163.com" class="auth_mail" title="E-mail the corresponding author ; Runqing Fu furunqing@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jiaqiang Liu liujqmj@163.com" class="auth_mail" title="E-mail the corresponding author ; Yong Wu wyonger@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Bo Wang wb228@126.com" class="auth_mail" title="E-mail the corresponding author ; Ning Jiang 179639060@qq.com" class="auth_mail" title="E-mail the corresponding author ; Ping Nie nieping1011@sina.com" class="auth_mail" title="E-mail the corresponding author ; Haifeng Cao 0412chf@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhi Yang ; wcums1981@163.com" class="auth_mail" title="E-mail the corresponding author ; Bing Fang ; fangbing@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADAM10 ; Maxillofacial bone ; Intramembranous bone formation ; Cranial neural crest cells
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：8 July 2016
- 年：2016
- 卷：475
- 期：4
- 页码：308-314
- 全文大小：1853 K
文摘
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We firstly reported that ADAM10 was essentially involved in maxillofacial bone development.
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ADAM10 cKO mice present craniofacial dysmorphia and bone defects.
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Impaired osteoblast differentiation,proliferation and apoptosis underlie the bone deformity.