- 作者：Dimitry S. Davydow ; Ruth Kohen ; Catherine L. Hough ; Julia Helen Tracy ; Douglas Zatzick ; Wayne J. Katon
- 关键词：Critical care ; Posttraumatic stress disorder ; Depression ; Corticotrophin-releasing hormone binding protein ; Corticotrophin-releasing hormone receptor-type 1
- 刊名：Journal of Critical Care
- 出版年：February, 2014
- 年：2014
- 卷：29
- 期：1
- 页码：101-106
- 全文大小：580 K
Purpose
To determine if single nucleotide polymorphisms of the corticotrophin-releasing hormone binding protein (CRHBP, rs10055255) and CRH receptor type 1 (CRHR1, rs1876831) were associated with posttraumatic stress disorder (PTSD) and depressive symptoms following medical-surgical intensive care unit (ICU) hospitalization.Materials and Methods
We extracted DNA for genotyping from saliva samples of 93 ICU patients enrolled in a prospective cohort investigation. Follow-up interviews conducted 3 and 12-months post-ICU included assessment of PTSD symptoms with the PTSD Checklist-Civilian Version and depressive symptoms with the Patient Health Questionnaire-9.
Results
Homozygosity for the CRHBP rs10055255 T allele was associated with significantly fewer post-ICU PTSD (尾 = 鈭?#xA0;10.8, 95% confidence interval [95% CI], 鈭?#xA0;17.7 to 鈭?#xA0;3.9; P = .002) and depressive symptoms (尾 = 鈭?#xA0;3.7, 95% CI, 鈭?#xA0;6.7 to 鈭?#xA0;0.7; P = .02). Carrying a CRHR1 rs1876831 C allele was associated with significantly more post-ICU depressive symptoms compared to T/T homozygotes (C/T heterozygtes: 尾 = 6.9, 95% CI, 1.2-12.6; P = .02; C/C homozygotes: 尾 = 5.8; 95% CI: 0.2-11.3; P = .04). These associations remained significant after adjustment for age, race, illness severity, and in-ICU steroid exposure.
Conclusions
Despite a small sample size, our findings suggest a potential role for genetic variants of CRHBP and CRHR1 in the development of post-ICU psychiatric morbidity.